Home >> Surgery >> ForumTopic: side effects of valproate - phamacology
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| bari Total Posts: 44 | Posted: Tue Oct 28, 2008 06:36 pm please help me with the question all are side effects of sod valproate except 1. fulminant hepatitis 2. PCOD 3. tremor 4. ataxia this question was asked in NIMHANS 2006 what KDT writes valproate causes fulminant hepatitis in children so LFT should be monitored regularly valproate is associated with PCOD in young females ataxia and tremor are dose related side effects. AAA gives the answer as PCOD but im still in a dilemma |
Total Posts: 7 | Posted: Thu Oct 30, 2008 12:13 am Hepatotoxicity is usually limited to children 2yrs of age or lower. The use of valproate with hepatic enzyme–inducing drugs increases the risk of liver toxicity. Menstrual irregularities and polycystic ovarian syndrome may appear in young women taking the drug, perhaps as a consequence of the aforementioned weight gain. Therefore the probable ans. wld be A. Ref: Adams Principles of Neurology 8th edt. |
| pavan14281 Total Posts: 3 | Posted: Thu Nov 06, 2008 05:23 am hi both katzung and goodman gilman dont mention pcod as a side effect. tremors and ataxia alongwith gi disturbances have been mentioned as very common, whereas fulminant hepatic failure, due to pentanoic acid, a maetabolite of valproate, has been mentioned alongwith thrombocytopenia as two idiosyncratic reactions. also carnitine is given to reduce/avoid hepatotoxicity. probably your answer is pcod. in a few pts, reversible weight gain is seen alongwith increase in appetite. i hope this helps |
| bari Total Posts: 44 | Posted: Fri Nov 07, 2008 05:42 am thanks pavan that was gr8  |