Home >> Study >> ForumTopic: Newer Drug Delivery systems
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| superbdoc Total Posts: 273 | Posted: Fri Oct 10, 2008 03:55 am GastroIntestinal therapeutic systemis a new system developed for certain drugs like nifedipine and dorazocin... Please discuss abt other newer systems...  |
| superbdoc Total Posts: 273 | Posted: Sat Oct 11, 2008 12:50 am Gastrointestinal therapeutic system (GTS) is proposed which is capable of delivering insoluble drug at a relatively constant rate. The unit consists of a tablet containing the insoluble drug and the soluble carrier, surrounded by a rate-controlling membrane with a delivery orifice. If the unit is in contact with fluid, water will pass constantly through the membrane into the tablet, dissolve the carrier which will be pumping out the insoluble drug through the delivery orifi |
| superbdoc Total Posts: 273 | Posted: Tue Oct 14, 2008 03:22 pm Whats your guess about OROS and MODAS..?? As u know a lot of abbreviations come for AIIMS...(remember PACS..??)
I will Ans in evening if no reply |
| juhidr Total Posts: 149 | Posted: Wed Oct 15, 2008 02:16 am OROS = osmotic-controlled release oral delivery system - an advanced drug delivery technology that uses osmotic pressure as the driving force to deliver pharmacotherapy, usually once-daily, in several therapeutic areas - OROS technology has evolved over the last 30 years, resulting in four systems: the elementary osmotic pump; the two-layer osmotic push-pull tablet; the advanced longitudinally compressed tablet multilayer formulation; and, the L-OROS system - OROS technology is employed for drug delivery in many therapeutic areas including: cardiovascular medicine, endocrinology, urology, and central nervous system (CNS) therapeutics - Two calcium channel blockers utilizing OROS technology for the treatment of hypertension are nifedipine and verapamil - Glipizide extended-release is used for the treatment of type 2 diabetes - Doxazosin is used for the treatment of benign prostatic hyperplasia - Oxybutynin for overactive bladder - Most recent developments are with drugs that affect the CNS, including the use of methylphenidate for treatment of attention deficit hyperactivity disorder, paliperidone extended-release and OROS hydromorphone, which are under clinical development for schizophrenia and chronic pain, respectively. - Drug delivery using the various OROS products can result in an improved safety profile, stable drug concentrations, uniform drug effects, and reduced dosing frequency - OROS technology has also enabled the use of an effective starting dose, without the need for dose titration, which allows the achievement of symptom control much earlier than that observed with immediate-release preparations. Such attributes can enhance patient compliance and convenience, thereby ensuring efficacy and improving patient outcomes. |
| juhidr Total Posts: 149 | Posted: Wed Oct 15, 2008 02:22 am MODAS = Multiporous oral drug absorptin system - specifically designed to control absorption of highly water soluble drugs - MODAS tablets are reservior systems which use a permeable membrane to control drug dissolution and allow diffusion from the tablet into the GIT |
| juhidr Total Posts: 149 | Posted: Wed Oct 15, 2008 02:23 am MODAS = Multiporous oral drug absorption system - specifically designed to control absorption of highly water soluble drugs - MODAS tablets are reservior systems which use a permeable membrane to control drug dissolution and allow diffusion from the tablet into the GIT |
| jemzcal Total Posts: 127 | Posted: Wed Oct 15, 2008 02:25 am great job. |
| juhidr Total Posts: 149 | Posted: Wed Oct 15, 2008 02:26 am thanks |
| juhidr Total Posts: 149 | Posted: Wed Oct 15, 2008 02:28 am infact while studying this i could learn few more things (that's why i like searching, as you never know what will aiims ask) |