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| superbdoc Total Posts: 273 | Posted: Mon Oct 06, 2008 05:22 am The French word boutonneuse means pimply. Also called Mediterranean spotted fever, fièvre boutonneuse, or Marseilles fever Due to Rickettsia conorii ; transmitted by the dog tick Rhipicephalus sanguineus. Boutonneuse fever is endemic in many countries surrounding the Mediterranean Sea. Fractalkine (CX3CL1) is a chemokine expressed mainly by endothelial cells, which are the major cellular targets of rickettsiae. After an incubation period of around seven days, the disease manifests abruptly with chills, high fevers, muscular and articular pains, severe headache and photophobia. The location of the bite forms a black crust (tache noire. Around the fourth day of the illness an exanthem (widespread rash) appears, first macular and then maculopapular and sometimes petechiae also. Tetracyclines together with chloramphenicol and quinolones may be considered first-line antibiotics. Patients presenting with the benign form of BF are usually on antibiotics for 7 d and those with the malignant form for 2 wk. |
| indent Total Posts: 54 | Posted: Tue Oct 07, 2008 05:09 am WOW  |