A) Peripheral blood monocytosis, more than 1 X 109/L B) Increased hemoglobin F levels for age C) Presence of bcr/abl fusion gene D) GM-CSF hypersensitivity of myeloid progenitors in vitro Answer (Select an option above to get the answer):
(Single Best Answer) Question 127: A 48 year old woman was admitted with a history of weakness for two months. On examination, cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5 g/dl, platelet count 237 X 109/L and total leukocyte count 40 X 109/L, which included 80 % mature lymphoid cells with coarse clumped choromatin. Bone marrow revealed a nodular lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD19, CD5, CD20 and CD23 and were negative for CD79B and FMC-7. What is the most likely diagnosis ?
A) T-cell rich B-cell lymphoma with leukemic spill over in blood B) Chronic lymphocytic leukemia C) Mantle cell lymphoma D) A definite diagnosis cannot be made in this patient without lymph node biopsy Answer (Select an option above to get the answer):