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Breast Cancer



Associations of Breast Cancer
A. Autosomal Dominant Conditions
BRCA-1 Mutation of Chr. 17q Malignancies of Breast, Ovary, Prostate, Colon
BRCA-2 Mutation of Chr. 13q Malignancies of Breast (including male), Ovary, Prostate, Pancreas, Larynx
Li-Fraumeni Syndrome Mutation in Chr. 17p (p53 gene) Malignancies of Breast, Brain, Adrenals, Soft tissue sarcomas
Muir-Torre Syndrome Mutation in Chr. 2p (Mismatch repair genes hMLH1, hMSH2) Malignancies of Breast, GI and Genitourinary Tract, Sebaceous tumors, Keratoacanthoma
Cowden Disease Mutation in Chr. 10q (PTEN gene) Malignancies of Breast, Bladder, Colon, Uterus, Thyroid, Lung, Hamartomatous polyps in GIT
Peutz-Jeghers Sydrome Mutation in Chr. 19p (STK11 gene) Malignancies of Breast, Pancreas, Hamartomas in GIT, Mucocutaneous melanin deposition
B. Autosomal Recessive Conditions
Ataxia telangiectasia