(Single Best Answer) Question 51: Diagnostic criteria of multiple myeloma includes which of the following ? 1. Increased malignant plasma cells in the bone marrow 2. Serum and/or urinary M protein 3. Skeletal lytic lesions 4. Skeletal blastic lesions
Select the correct answer using the code given below:
A) 1, 2 and 3 B) 1, 3 and 4 C) 1, 2 and 4 D) 2, 3 and 4 Answer (Select an option above to get the answer):
A) It is a clonal malignancy of haematopoetic stem B) Risk of developing CML is increased in monozygotic twins C) CMLS is defined by presence of BCR-ABL 1 fusion gene D) 10 year survival with TKI therapy is 85% Answer (Select an option above to get the answer):
(Single Best Answer) Question 53: Every individual carries four alpha gene alleles. Deletion of three alleles leads to development of ?
A) Haemoglobin X disease B) Haemoglobin H disease C) Haemoglobin F disease D) Hydrops fetalis Answer (Select an option above to get the answer):
A) Infectious mononucleosis B) Chronic leukaemia C) Both infectious mononucleosis and chronic leukaemia D) Neither infectious mononucleosis nor chornic leukaeia Answer (Select an option above to get the answer):
A) Acute chest syndrome B) Aplastic crisis C) Splenic sequestration crisis D) Conn's syndrome Answer (Select an option above to get the answer):
(Single Best Answer) Question 56: Pyruvate kinase deficiency results in deficiency of ATP production and a chronic haemolytic anaemia. The disorder is inherited as an ?
A) Autosomal recessive trait B) X-linked recessive trait C) Autosomal dominant trait D) X-linked dominant trait Answer (Select an option above to get the answer):
A) Hemolytic anemia B) Megaloblastic anemia C) Post splenectomy D) Chronic inflammatory disorders Answer (Select an option above to get the answer):
(Single Best Answer) Question 59: Which one of the following investigations is NOT appropriate in a case of recurrent thrombosis ?
A) Antiphospholipid antibodies B) Bcr-Abl assay C) Protein C and S assays D) Antithrombin level Answer (Select an option above to get the answer):
(Single Best Answer) Question 60: A 35 year old man presents with history of low grade fever and headache for last five weeks. Clinical examination is remarkable for signs of meningismus. He undergoes lumbar puncture (LP) and a day later reports worsening of headache. Which one of the following features is NOT consistent with diagnosis of 'Post-LP' headache ?
A) Post-LP headache usually begins within 48 hours B) Post-LP headache worsens in sitting position C) Post-LP headache is most severe upon waking up D) Post-LP headache may improve with caffeine intake Answer (Select an option above to get the answer):