A) Blasts of acute myeloid leukemia are typically sudan black negative B) Blasts of acute lymphoblastic leukemia are typically myeloperoxidase positive C) Low leucocyte alkaline phosphatase score is characteristically seen in blastic phase of chronic myeloid leukemia D) Tartarate resistant acid phosphatase positivity is typically seen in hairy cell leukemia Answer (Select an option above to get the answer):
A) Formation of amorphous densities in the mitochondrial matrix B) Diminished generation of adenosine triphosphate (ATP) C) Formation of blebs in the plasma membrane D) Detachment of ribosomes from the granular endoplasmic reticulum Answer (Select an option above to get the answer):
A) Malignant hypertension B) Polyarteritis nodosa C) Diabetic glomerulosclerosis D) Aschoff's nodule Answer (Select an option above to get the answer):
A) Takayasu disease B) Mucocutaneous lymph node syndrome (Kawasaki disease) C) Henoch Schonlein purpura D) Polyarteritis nodosa Answer (Select an option above to get the answer):
(Single Best Answer) Question 1175: A four year old boy was admitted with a history of abdominal pain and fever for two months, maculopapular rash for ten days, and dry cough, dyspnea and wheezing for three days. On examination, liver and spleen were enlarged 4 cm and 3 cm respectively below the costal margins. His hemoglobin was 10.0 g/dl, platelet count 37 x 109/L and total leukocyte count 70 x 109/L, which included 80% eosinophils. Bone marrow examination revealed a cellular marrow comprising 45% blasts and 34% eosinophils and eosinophilic precursors. The blasts stained negative for myeloperoxidase and non-specific esterase and were positive for CD 19, CD 10, CD22 and CD20. Which one of the following statements in not true about this disease ?
A) Eosinophils are not part of the neoplastic clone B) t(5; 14) rearrangement may be detected in blasts C) Peripheral blood eosinophilia may normalize with chemotherapy D) Inv (16) is often detected in the blasts and the eosinophils Answer (Select an option above to get the answer):
(Single Best Answer) Question 1176: Kidney biopsy from a child with hemolytic uremic syndrome characteristically most likely presents features of ?
A) Thrombotic microangiopathy B) Proliferative glomerulonephritis C) Focal segmental glomerulosclerosis D) Minimal change disease Answer (Select an option above to get the answer):
A) It is used in the medical treatment of benign prostatic hypertrophy (BPH) B) Impotence is well documented after its use C) It blocks the conversion of dihydrotestosterone to testosterone D) It is a 5-á-reductase inhibitor Answer (Select an option above to get the answer):
A) It is a brain natriuretic peptide analogue B) is used in acutely decompensated heart failure C) It has significant oral absorption D) It has a short half-life Answer (Select an option above to get the answer):